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Synthesis of a new class of retinoid, 3 H‐labelled TTNPB, 1 with a high specific activity
Author(s) -
Rhee Sung W.,
Degraw Joseph I.,
Kaegi Heinz H.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220812
Subject(s) - chemistry , benzoic acid , tritium , specific activity , derivative (finance) , radiochemistry , stereochemistry , biochemistry , enzyme , physics , nuclear physics , financial economics , economics
Synthetic procedures for tritiation of a retinodal benzoic acid derivative, (E)‐4‐[2‐(5,6,7,8‐tetrahydro‐5,5,8,8‐tetramethyl‐2‐naphthalenyl‐6,7‐ 3 H 2 )‐1‐propenyl]‐benzoic acid, (TTNPB), are described. Tritium was introduced by catalytic hydrogenation. The final product, TTNPB‐ 3 H 2 (9), had a specific activity of 24.1 Ci/mmole and a radiochemical purity of 95.6%.