Premium
Synthesis of 1‐ 13 C‐1‐indanone and 2‐ 13 C‐1,2,3,4‐tetrahydroquinoline
Author(s) -
Pickering R. E.,
Wysocki M. A.,
Eisenbraun E. J.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220811
Subject(s) - chemistry , yield (engineering) , hydrazone , stereochemistry , physics , thermodynamics
The synthesis of 2‐ 13 C‐1,2,3,4‐tetrahydroquinoline (5) via 1‐ 13 C‐3‐phenylpropanoic acid (1), 1‐ 13 C‐1‐indanone (2), 1‐ 13 C‐1‐indanone hydrazone (3) and 2‐ 13 C‐3,4‐dihydro‐2(1H)‐quinolinone (4) proceeded in 78, 96, 95, 79, and 85% individual yields respectively for 1, 2, 3, 4, 5 and 61% overall yield of the latter from 1.