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Synthesis of |24‐ 14 C|‐3β,14β,20ε‐trihydroxy‐23‐nor‐5β‐cholanoic acid
Author(s) -
Maier M. S.,
Seldes A. M.,
Gros E. G.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220810
Subject(s) - chemistry , reformatsky reaction , digitoxigenin , stereochemistry , medicinal chemistry , glycoside
The synthesis of |24‐ 14 C|‐3β,14β,20ε‐trihydroxy‐23‐nor‐5β‐cholanoic acid was accomplished by Reformatsky reaction of ethyl |1‐ 14 C|‐bromo acetate with 3β‐acetoxy‐14β‐hydroxy‐5β‐pregnan‐20‐one which was obtained from digitoxigenin. The final and intermediate products were characterized by spectroscopic (IR, 1 H and 13 C‐NMR, MS) methods.