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Synthesis of 2‐n butyl 3‐(3,5‐ 125 diiodo 4‐(N, N‐diethylamino 2‐ethoxybenzoyl)) benzofuran hydrochloride ( 125 I amiodarone)
Author(s) -
Sion R.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220807
Subject(s) - chemistry , benzofuran , yield (engineering) , medicinal chemistry , amination , halogenation , hydrochloride , carbon 14 , nuclear chemistry , radiochemistry , organic chemistry , materials science , metallurgy , catalysis , physics , quantum mechanics
Abstract 125 I Amiodarone was prepared by iodination of 2‐n butyl 4‐hydroxy 3‐benzoyl benzofuran with Na 125 I in alkaline medium. By amination with N, N‐diethyl 2‐amino 1‐chloroethane, 125 I amiodarone was obtained with 30 % yield and a specific activity of about 1 Ci/mmol.