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A convenient synthesis of [1‐ 14 C]acetylcholine iodide
Author(s) -
Anjaneyulu B.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220715
Subject(s) - chemistry , iodide , acetic anhydride , yield (engineering) , methyl iodide , acetylcholine , acetylation , iodine , organic chemistry , radiochemistry , biochemistry , catalysis , medicine , materials science , metallurgy , gene , endocrinology
A convenient synthesis of [1‐ 14 C]acetylcholine iodide in two steps is described. β‐Dimethylaminoethanol is acetylated with [1‐ 14 C]acetic anhydride and the ester β‐dimethylaminoethyl [1‐ 14 C]acetate quaternised with methyl iodide to afford [1‐ 14 C]acetylcholine iodide in an overall material yield of 50–52% and radiochemical yield 18%.