Premium
Synthesis of 1‐[ 14 C]‐phenyl‐1‐(3,4‐dimethyl)phenylethane, a component of some PCB replacement materials
Author(s) -
Willis D. E.,
Addison R. F.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220711
Subject(s) - chemistry , bromobenzene , yield (engineering) , reagent , solvent , alcohol , medicinal chemistry , capacitor , organic chemistry , catalysis , materials science , metallurgy , physics , quantum mechanics , voltage
1‐[ 14 C]‐phenyl‐1‐(3,4‐dimethyl)phenylethane, a labeled analogue of a PCB replacement used as an ink solvent in pressure sensitive copying paper and as a capacitor dielectric, has been prepared. The Grignard reagent derived from 14 C‐bromobenzene was condensed with methyl(3,4‐dimethyl)phenylketone and the resulting tertiary alcohol was hydrogenolyzed. The final yield was 53.1% based on 14 C‐bromobenzene; final specific activity of the product was 1.29 mCi·mmole −1 , which is adequate for metabolic studies.