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Aromatic fluorination with N.C.A. F‐18 fluoride: A comparative study
Author(s) -
Berridge M. S.,
Crouzel C.,
Comar D.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220708
Subject(s) - chemistry , aryl , nucleophilic aromatic substitution , fluoride , inert , nucleophile , solvent , halogenation , fluorine , medicinal chemistry , nucleophilic substitution , electrophilic aromatic substitution , hydrogen fluoride , organic chemistry , inorganic chemistry , catalysis , alkyl
Fluorination of aromatic rings with no carrier added (n.c.a.) 18 F‐fluoride was investigated using aryl triazenes and aryl iodides as substrates. Aryl triazenes give low yields of labeled under all conditions, and evidence was obtained to indicate that an inert solvent was unnecessary for the reaction. Nucleophilic substitution of aromatic iodides in DMSO was found to be a superior method of fluorination yielding up to 70% incorporation of label. The scope and limitations of this new labeling reaction are reported.