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Routine production of 2‐deoxy‐ D ‐[1‐ 11 C]glucose : An alternative
Author(s) -
van Haver D.,
Rabi N. A.,
Vandewalle M.,
Goethals P.,
Vandecasteele C.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220704
Subject(s) - chemistry , formic acid , yield (engineering) , high performance liquid chromatography , hydrolysis , nitrile , tritium , specific activity , nuclear chemistry , chromatography , cyanide , ion exchange , radiochemistry , organic chemistry , ion , enzyme , materials science , metallurgy , physics , nuclear physics
The routine production of 2‐deoxy‐D‐[1‐ 11 C]glucose ( 11 C‐glucose ( 11 C‐2DG) from [ 11 C]hydrogen cyanide and 2,3:4,5‐di‐O‐isopropylidene‐1‐iodo‐D‐arabinitol is described. The nitrile intermediate is purified by high‐performance liquid chromatography (HPLC) before reduction/hydrolysis with Raney alloy in formic acid. The radiopharmaceutical is isolated by ion exchange and is obtained in a radiochemical yield of 20 % with a synthesis time of 50–55 min. A typical run affords 25–30 mCi of 11 C‐2DG with a specific activity of 90–100 mCi/mg.