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Synthesis of racemic [2‐ 11 C]phenylglycine
Author(s) -
Halldin Christer,
Långström Bengt
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220613
Subject(s) - chemistry , benzaldehyde , yield (engineering) , benzoic acid , strecker amino acid synthesis , salt (chemistry) , chemical synthesis , organic chemistry , nuclear chemistry , catalysis , enantioselective synthesis , biochemistry , materials science , metallurgy , in vitro
The synthesis of racemic [2‐ 11 C]phenylglycine, starting with 11 CO 2′ is reported. The [ 11 C]benzaldehyde, prepared as previsously described in a two‐step reaction from the corresponding [ 11 C]benzoic acid salt, was used in a modified Bücherer‐Strecker reaction. The radiochemical yield of [2‐ 11 C]phenylglycine in benzaldehyde‐added experiments was 20 %, and in non‐added experiments 6 % (corrected for decay). The overall synthesis time, starting with 11 CO 2 , was 50 min (including LC separation). The radiochemical purity was higher than 99 %.