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Regioselective labelling of anilides with deuterium
Author(s) -
Lockley W J S
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220612
Subject(s) - chemistry , regioselectivity , deuterium , labelling , nitrogen atom , aryl , chloride , medicinal chemistry , organic chemistry , catalysis , ring (chemistry) , alkyl , quantum mechanics , biochemistry , physics
N‐Aryl amides may be deuterated by exchange with deuterium oxide in the presence of rhodium (III) chloride. Under such conditions deuterium is introduced into positions ortho to the anilide nitrogen atom with a high degree of regioselectivity.