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Synthesis of [4′‐ 13 C] pyridoxol
Author(s) -
Velde V. W. Vande,
Mackenzie N. E.,
Scott A. I.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220609
Subject(s) - chemistry , cyanide , sodium cyanide , medicinal chemistry , sodium , stereochemistry , nitrile , organic chemistry
5‐Cyano‐3‐hydroxy‐2‐methylpyridine‐l‐oxide, after O‐methylation with dimethylsulfate, was reacted regiospecifically with sodium [ 13 C] cyanide to give [4′‐ 13 C] 4,5‐dicyano‐3‐hydroxy‐2‐methylpyridine. The latter compound was successively transformed to [4′‐ 13 C] pyridoxol and [4′‐ 13 C] pyridoxal phosphate.