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Production of 11 C‐labeled quinidine and tamoxifen
Author(s) -
Van Haver D.,
Vandewalle T.,
Slegers G.,
Vandecasteele C.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220603
Subject(s) - chemistry , quinidine , radiochemistry , yield (engineering) , high performance liquid chromatography , tamoxifen , nuclear chemistry , potassium , chromatography , pharmacology , medicine , organic chemistry , cancer , breast cancer , metallurgy , materials science
The production of [ 11 C] quinidine and [ 11 C] tamoxifen for use with positron emission tomography is described. The potassium salt of O‐desmethylquinidine and N‐desmethyltamoxifen free base are treated with [ 11 C]methyl iodide at 130°C for 10 min. After HPLC separation, the [ 11 C‐methyl]‐labeled compounds are produced with a radiochemical yield of 60 and 70 % respectively. Injectable activities from 50 to 70 mCi are obtained 1 h after the irradiation; the specific activity is 40–60 mCi/μ mole. The entire production is controlled by a microprocessor.