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Synthesis of 4‐fluoro‐4′‐trifluoromethylbenzophenone guanylhydrazone hydrochloride labeled with 14 C
Author(s) -
Wang Theodore S. T.,
Fawwaz Rashid A.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220413
Subject(s) - chemistry , carboxylation , hydrochloride , aldehyde , yield (engineering) , hydrazone , chloride , condensation , condensation reaction , medicinal chemistry , organic chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
Four steps were required to synthesize the title compound. This involved carboxylation, acid chloride formation, condensation, and hydrazone formation. The overall radiochemical yield was 12.5% amd the specific activity was 2.04 mCi/mmole. Because of the difficulty encountered in preparing the p‐fluorobenzal‐dehyde‐aldehyde‐ 14 C, p‐fluorobenzoyl chloride‐carbonyl 14 C was used for the condensation reaction.