Premium
Synthesis of 14 C‐labeled halogen substituted indole‐3‐acetic acids
Author(s) -
Baldi Bruce G.,
Slovin Janet Pernise,
Cohen Jerry D.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220309
Subject(s) - chemistry , halogen , acetic acid , indole test , benzene , hydrazine (antidepressant) , microscale chemistry , indole 3 acetic acid , organic chemistry , ring (chemistry) , medicinal chemistry , chromatography , biochemistry , alkyl , mathematics education , mathematics , gene , auxin
A general method for microscale synthesis of 14 C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [ 14 C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐Chlorophenyl‐hydrazine yielded a mixture of the 4 and 6 chloro compounds that was resolved by C 18 ‐reverse phase high performance liquid chromatography.