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Synthesis of 14 C‐labelled 1‐(3,5‐bis‐trifluoromethyl)‐phenyl‐4‐methyl thiosemicarbazide, C 2696‐GO
Author(s) -
Maller R. K.,
Nagarajan K.,
Zoebeli H.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220303
Subject(s) - chemistry , moiety , trifluoromethyl , yield (engineering) , potassium thiocyanate , medicinal chemistry , thiocyanate , stereochemistry , organic chemistry , alkyl , materials science , metallurgy
For pharmacokinetic and metabolism studies in experimental animals C 2696‐Go was labelled initially with 14 C on the thiocarbonyl carbon of the thiosemicarbazide moiety of the molecule, having a specific activity of 3.14 μCi/mg, in a radiochemical yield of 43%, based on the starting potassium [ 14 C]thiocyanate. C 2696‐Go alternatively labelled with 14 C on one of the trifluoromethyl groups, having a specific activity of 3.6 μCi/mg was also synthesized in an overall radiochemical yield of 5.1%, starting from Ba[ 14 C]O 3 .