Premium
Synthese DU cyclopropylmethyl‐2 di(paramethoxyphenyl)‐5,6 oxo‐3 triazine‐1,2,4 ( 14 C‐3) (ST 1118)
Author(s) -
Bonnaud B.,
Cousse H.,
Noël J. P.,
Pichat L.,
Pitet G.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220113
Subject(s) - chemistry , semicarbazide , cyclopropane , urea , hydrochloride , hydrate , yield (engineering) , medicinal chemistry , hydrazine (antidepressant) , nuclear chemistry , chromatography , organic chemistry , ring (chemistry) , materials science , metallurgy
( 14 C) semicarbazide hydrochloride was obtained from ( 14 C) urea and hydrazine hydrate. It was condensed with 1,2‐di‐ (4‐methoxy phenyl)‐ethane‐1,2‐dione giving rise to 5, 6‐di‐(4‐methoxyphenyl)‐3‐oxo‐(3‐ 14 C)‐1,2,4‐triazine. The latter, after condensation with bromomethyl cyclopropane gave (3‐ 14 C) ST 1118 : 2‐(cyclopropylmethyl)‐5,6‐di‐(4‐methoxyphenyl)‐3‐oxo‐(3‐ 14 C)‐1,2,4‐ triazine. The overall yield based on urea was 37.2%. After silicagel column chromatography and crystallisation the radiochemical purity was 99.5% ‐ Specific activity : 5.8 mCi/mMole.