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Synthesis of 3‐[ 3 H]‐5‐(4′‐azobenzene arsonic acid)‐L‐tyrosine
Author(s) -
Brundish D. E.,
Wade R.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220107
Subject(s) - chemistry , tyrosine , high performance liquid chromatography , specific activity , azobenzene , tritium , chromatography , radiochemistry , chemical synthesis , organic chemistry , nuclear chemistry , biochemistry , enzyme , molecule , in vitro , physics , nuclear physics
The title compound (ABA‐Tyr) was prepared by direct radiochemical synthesis from tritiated tert .‐butoxycarbonyl‐L‐tyrosine and diazotised arsanilic acid followed by acidolytic deprotection and isolation by preparative high pressure liquid chromatography. The product had a specific activity of 9 Ci mmol −1 and a radiochemical purity of 90–95%.