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synthesis of 10‐[ 3 H]‐5H‐dibenz[b, f] azepine‐5‐carboxamide ([ 3 H]‐carbamazepine)
Author(s) -
Brundish D. E.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220106
Subject(s) - chemistry , azepine , bromine , carboxamide , catalysis , catalytic hydrogenation , tritium , medicinal chemistry , derivative (finance) , double bond , selective catalytic reduction , stereochemistry , radiochemistry , organic chemistry , financial economics , economics , physics , nuclear physics
The title compound has been prepared from a bromo derivative at a specific activity of 27 Ci mmol −1 with radiochemical purity of 98.4% by a selective catalytic reduction with tritium gas. Bromine was replaced without reduction of the stilbene double bond using a poisoned, deactivated catalyst.
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