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Fast low temperature ultrasonic synthesis and injection ready preparation of carrier free 17‐I‐123‐heptadecanoic acid
Author(s) -
Mertens John,
Vanryckeghem Wim,
Bossuyt Axel,
Van Den Winkel Pierre,
Vandendriessche René
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210908
Subject(s) - chemistry , sonication , yield (engineering) , chromatography , cartridge , nucleophile , dissociation (chemistry) , organic chemistry , catalysis , mechanical engineering , materials science , engineering , metallurgy
17‐I‐123‐heptadecanoic acid is prepared carrier‐free from 17‐Br‐heptadecanoic acid in methyl ethyl ketone at 100°C. A quantitative labeling yield is obtained within 20 minutes using a 50 KHz ultrasonic bath. Sonication allows the presence of water up to 7.5% v/v. The pattern shown by the plot of the kinetic curves is typical of two consecutive reactions: the first being the dissociation of a radioactive side product, the second a I − for Br nucleophilic exchange. The pure carrier‐free radioiodinated fatty acid is obtained by HPLC separation and is used clinically in a sterile 6% human serum albumine solution. The quality control of the injection ready solution is based on the use of a RP18 Sep‐Pak R cartridge.