Premium
Labeled bile acids V: Deuterium and carbon‐13 labeled cholic, chenodeoxycholic and ursodeoxycholic acids
Author(s) -
Lai Chee Kong,
Byon Chang Yon,
Gut Marcel,
Mostowicz Danuta,
Anderson Warren G.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210705
Subject(s) - chemistry , chenodeoxycholic acid , cholic acid , phosphorane , ursodeoxycholic acid , deuterium , wittig reaction , carbon tetrachloride , kinetic isotope effect , organic chemistry , bile acid , biochemistry , physics , quantum mechanics
This paper describes a general, simple and short procedure for the introduction of stable isotopes (deuterium and carbon‐13) to the side chain of bile acids. The bisnorcholyl aldehydes of cholic and chenodeoxycholic acids are key intermediates, while the isotope is introduced by the Wittig condensation of [1,2‐ 13 C 2 ]‐(carbethoxymethylene)triphenyl‐phosphorane.