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Deuterium, tritium, and carbon‐14 labeling of 9‐[ [2‐methoxy‐4‐[ (methylsulfonyl)amino]phenyl] amino]‐N, 5‐dimethyl‐acridinecarboxamide (CI‐921), a new antitumor agent
Author(s) -
Hays Sheryl J.,
Huang C. C.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210611
Subject(s) - chemistry , tritium , yield (engineering) , deuterium , radiochemistry , carbon 14 , benzoic acid , salt (chemistry) , catalysis , specific activity , carbon fibers , nuclear chemistry , medicinal chemistry , organic chemistry , materials science , physics , quantum mechanics , composite number , nuclear physics , metallurgy , composite material , enzyme
CI‐921 2 , a potent antitumor agent has been labeled with deuterium and tritium by an exchange reaction employing platinum black as a catalyst. The title compound was carbon‐14 labeled from 2‐chloro‐benzoic‐carboxy‐ 14 C acid to produce the isethionic salt 2d with a specific activity of 26.9 mCi/mmol. The overall radiochemical yield for the carbon‐14 sequence was 22%.