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Application of the nucleophilic substitution reaction to the synthesis of No‐carrier‐added [ 18 F]fluorobenzene and other 18 F‐labeled aryl fluorides
Author(s) -
Shiue C.Y.,
Watanabe M.,
Wolf A. P.,
Fowler J. S.,
Salvadori P.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210607
Subject(s) - fluorobenzene , chemistry , nucleophilic substitution , aryl , yield (engineering) , butyrophenone , nucleophilic aromatic substitution , nitro , medicinal chemistry , nitro compound , nucleophile , organic chemistry , catalysis , benzene , alkyl , materials science , neuroscience , dopamine , metallurgy , haloperidol , biology
No‐carrier‐added (NCA) [ 18 F]fluorobenzene was prepared in a multistep synthesis with a radiochemical yield of 20‐30%. A series of NCA and CA 18 F‐labeled aryl fluorides which are important precursors of 18 F‐labeled butyrophenone neuroleptics have also been synthesized in radiochemical yields of 30–50%. The direct synthesis of [ 18 F]spiroperidol and [ 18 F]benperidol from the parent compounds and/or nitro and/or chloro compound using the nucleophilic substitution reactions were also investigated.