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Synthesis of carbon‐14 and carbon‐13 labeled 3‐methyl‐6‐[3‐(trifluoro‐methyl)phenyl]‐1,2,4‐triazolo[4,3‐b]pyridazine
Author(s) -
May M. K.,
Lanzilotti A. E.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210511
Subject(s) - chemistry , pyridazine , yield (engineering) , carbon 14 , trifluoromethyl , carbon fibers , anxiolytic , stereochemistry , organic chemistry , biochemistry , materials science , physics , alkyl , receptor , quantum mechanics , composite number , metallurgy , composite material
3‐Methyl‐6‐[3‐(trifluoromethyl)phenyl]‐1,2,4‐triazolo[4,3‐b] pyridazine ( 4 ), currently being evaluated as a potential anxiolytic agent was synthesized, labeled with carbon‐14 in the 3‐position of the triazolo nucleus. The product was obtained in 67% radiochemical yield with specific activity of 13.5 mCi/mmol and radiopurity of greater than 99%. The carbon‐13 labeled compound was also synthesized for absorption and metabolism studies.