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Multi‐ 13 C‐labelled 2,4‐diamino‐6‐methylpteridine
Author(s) -
Cheung H. T. A.,
Gray P. G.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210509
Subject(s) - chemistry , acetone , sodium cyanide , carbon 13 nmr , cyanide , medicinal chemistry , organic chemistry , nuclear chemistry
Samples of 2,4‐diamino‐6‐methylpteridine (1), specifically labelled with 13 C at one or more carbon positions, were synthesised using a combination of the appropriate unlabelled and the following 13 C‐labelled starting materials ( ca. 90% 13 C): acetone‐2‐ 13 C, acetone‐1,3‐ 13 C, bromoacetic acid‐1‐ 13 C, bromoacetic acid‐2‐ 13 C, sodium cyanide‐ 13 C, and guanidine‐ 13 C. The identity and site(s) of 13 C of each final product and intermediate were established by 13 C‐and 1 H‐NMR.