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Preparation of [ 18 O]‐chlorocarbonylsulfenyl chloride
Author(s) -
Mott Andrew W.,
Eastep Steven J.,
Słomczynska Urszula,
Barany George
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210407
Subject(s) - chemistry , chloride , hydrolysis , dioxolane , distilled water , medicinal chemistry , nuclear chemistry , radiochemistry , organic chemistry , chromatography
[ 18 O]‐Chlorocarbonylsulfenyl chloride with an isotopic purity of 92% was prepared in three steps starting with the [ 18 O]‐hydrolysis of 2‐ethyl‐1,3‐dioxolane to [ 18 O]‐propanal, which was then converted to [ 18 O]‐ O ‐1‐methylpropyl S ‐methyl dithiocarbonate, which was then chlorinated to give the title compound. Distilled yields for the three steps were 57%, 49%, and 40% respectively.