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Synthesis of tritiated bumetanide
Author(s) -
Wyrick Steven D.,
MorrisNatschke Susan,
Lauf Peter K.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210210
Subject(s) - chemistry , tritium , rhodium , tritium illumination , palladium , catalysis , tris , homogeneous , bumetanide , phosphine , chloride , deuterium , radiochemistry , medicinal chemistry , organic chemistry , biochemistry , physics , quantum mechanics , nuclear physics , thermodynamics , cotransporter , sodium
Tritium Iabelled bumetanide of high specific activity (16 Ci/mmol) has been prepared in our laboratory by tris(triphenyl‐phosphine) rhodium chloride catalyzed reduction of an olefinic precursor with carrier free tritium gas in benzene‐ethanol (1:1). The product is labelled in the N‐butyl side chain. Comparison of both heterogeneous palladium and homogeneous rhodium catalyzed deuterium reductions as a model for the tritiation revealed that the latter reduction was accompanied by considerably less label scrambling.