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Stereospecific synthesis of adenosine cyclic 3′,5′‐R P ‐ and S P ‐phosphoro‐[ 35 S]thioates
Author(s) -
Baraniak Janina,
Reimschüssel Wtadystaw,
Rudziński Juliusz,
Stec Wojciech J.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210204
Subject(s) - stereospecificity , chemistry , diastereomer , sodium hydride , adenosine , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , catalysis
Stereospecific reaction of both diastereoisomers of O 2′ ,N 6 ,N 6 ‐tribenzoyladenosine cyclic 3′,5′‐phosphoranilidates ( 1 ) with sodium hydride and carbon [ 35 S]disulphide gave, after removal of the protective groups, the desired R P — and S P ‐diastereoisomers of [ 35 S]cAMPS ( 2 ).