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Labeled bile acids I: Synthesis of 18 O‐methyl hydroxy‐5β‐cholan‐24‐oates
Author(s) -
Anderson Warren G.,
Byon Chang Yon,
Eck Charles R.,
Gut Marcel
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210106
Subject(s) - chemistry , hydrolysis , acetal , ketone , bile acid , hydride , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , hydrogen
The incorporation of 18 O into the 3‐hydroxyl of bile acids has been accomplished by hydrolysis of the acetal corresponding to the 3‐oxo bile acid with H 2 O, followed by hydride reduction of the ketone to the labeled hydroxyl function.