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Synthesis of tritium labeled zomepirac
Author(s) -
Hoerr David C.,
Scharf Ann T.,
Carson John R.,
Weaner Larry E.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201210
Subject(s) - chemistry , tritium , alkylation , methyl iodide , desmethyl , radiochemistry , iodide , solvent , organic chemistry , catalysis , biochemistry , physics , metabolite , nuclear physics
Tritium labeled zomepirac with a specific activity of 85 Ci/mol was prepared by selective alkylation of the penultimate desmethyl precursor using methyl iodide‐ 3 H 3 . The alkylation reaction was explored using various bases and solvent media.