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Synthesis of 14 C‐labelled 1‐(2,6‐dimethyphenylamino)‐2‐dimethylamino‐propane
Author(s) -
Zólyomi G.,
Zubovics Z.,
Toldy L.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201202
Subject(s) - chemistry , propane , chloride , radiochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
The antiarrhytmic 1‐(2,6‐dimethylphenylamino)‐2‐dimethylamino‐propane ( 6a ) was labelled with 14 C for pharmacokinetic study. A convenient synthesis, using 2‐bromopropionyl‐1‐ 14 C chloride as radioactive key intermediate, involving an improved method for the reduction of N‐(2‐dimethylaminopropionyl)‐2,6‐dimethylaniline ( 8 ) was elaborated.