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Synthesis of hexadeuterated diethylstilbestrol ([1,1,1,6,6,6‐d6]‐E‐3,4‐di‐(4‐hydroxyphenyl)‐hex‐3‐ene)
Author(s) -
Zomer Gijsbert,
Derks Henk J. G. M.,
Wynberg Hans
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201104
Subject(s) - chemistry , ene reaction , diethylstilbestrol , alpha (finance) , cadmium , beta (programming language) , coupling reaction , medicinal chemistry , stereochemistry , radiochemistry , organic chemistry , catalysis , hormone , biochemistry , medicine , construct validity , nursing , computer science , patient satisfaction , programming language
[1,1,1,6,6,6‐d6]‐E‐3,4‐di‐(4‐hydroxyphenyl)‐hex‐3‐ene was synthesized from [1,1,1‐d3]‐4‐methoxypropiophenone by reductive coupling. The preparation of [1,1,1‐d3]‐4‐methoxypropiophenone involved reaction of p‐anisoylchloride with perdeuterated diethyl‐cadmium followed by back‐exchange of the alpha protons.