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Triethyl [1‐ 14 C]phosphonoacetate from [ 14 C]carbon dioxide
Author(s) -
Crevoisier Michel,
Guilford William J.,
Coates Robert M.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201012
Subject(s) - chemistry , carbonation , carbon dioxide , yield (engineering) , nuclear chemistry , organic chemistry , radiochemistry , metallurgy , materials science
Lithiation of diethyl methylphosphonate ( 1 ) with n ‐butyllithium followed by carbonation with [ 14 C]carbon dioxide and esterification with diazoethane afforded high specific activity triethyl [1‐ 14 C]phosphonoacetate ( 4 ) in 62% yield.