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Preparation of specifically‐labelled buspirone ‐ 14 C and buspirone ‐ 15 N 2
Author(s) -
Covington R. R.,
New J. S.,
Yevich J. P.,
Temple D. L.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201011
Subject(s) - buspirone , chemistry , anxiolytic , urea , anticonvulsant , sedative , pharmacology , organic chemistry , biochemistry , psychology , receptor , agonist , neuroscience , epilepsy , medicine
Buspirone 1 is a novel, clinically effective anxiolytic agent which is devoid of the sedative, anticonvulsant or muscle relaxant properties normally associated with the benzodiazepines. Buspirone labelled with both radioactive ( 14 C) and stable ( 15 N) isotopes was required in order to investigate the metabolism of the compound. The synthesis of both labelled compounds beginning with either urea ‐ 14 C or urea ‐ 15 N 2 is described.