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Synthesis of 35 S‐ and 14 C‐labeled famotidine, a new potent histamine H 2 receptor antagonist
Author(s) -
Tamazawa Kazuharu,
Arima Hideki
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201009
Subject(s) - famotidine , chemistry , histamine , antagonist , thio , histamine receptor , histamine h2 receptor , cimetidine , stereochemistry , receptor antagonist , receptor , pharmacology , biochemistry , medicine
Famotidine, 3‐[[[2‐[(diaminomethylene)amino]‐4‐thiazolyl]methyl]thio]‐ N 2 ‐sulfamoylpropionamidine, a new potent histamine H 2 receptor antagonist, was labeled with 35 S and 14 C for metabolic studies at specific activities of 45.7 μCi/mg (VIb) and 47.6 μCi/mg (VIc) respectively.