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Synthesis and biodistribution of radioiodinated‐5‐iodonicotine
Author(s) -
Chan S. M.,
Basmadjian G. P.,
Marten D. F.,
Sadek S. A.,
Magarian R. A.,
Grunder J. R.,
Ice R. D.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200813
Subject(s) - biodistribution , chemistry , radiochemistry , specific activity , adrenal gland , acetic acid , yield (engineering) , sulfate , copper sulfate , chromatography , nuclear chemistry , biochemistry , endocrinology , organic chemistry , copper , in vitro , medicine , materials science , enzyme , metallurgy
5‐Bromonicotine, synthesized from nicotinic acid, was autoclaved with Na 125 I in the presence of copper sulfate and glacial acetic acid to give 5‐[ 125 I]iodonicotine. The radiochemical yield was 25.3%. The specific activity of the product was approximately 61 mCi/mmole. Biodistribution studies of 5‐[ 125 I]iodonicotine, performed in rats, showed that the labelled compound accummulated rapidly in the brain and the adrenal gland. The highest uptake of radioactivity in these organs occurred at 5 minutes after administration. The brain‐to‐blood and the adrenal‐to‐blood ratios at this time interval were 2.6:1 and 3.3:1 respectively.