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Synthesis of 2,4′,5‐trichloro [ 14 C]biphenyl mercapturic acids
Author(s) -
Bergman Ake,
Bakke Jerome E.,
Feil Ver J.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200806
Subject(s) - chemistry , biphenyl , aniline , amine gas treating , mercapturic acid , medicinal chemistry , aryl , organic chemistry , cysteine , alkyl , enzyme
The synthesis of 3‐ and 4‐S‐(N‐acetyl)cysteinyl‐2,4′,5‐trichloro[ 14 C]biphenyl is described. 4‐Chloro[ 14 C]aniline was used as starting material. The products were obtained after an aryl coupling of the amine with 2,5‐dichloronitrobenzene, a reduction of the nitrogroup and finally coupling of the diazotized trichlorobiphenyl amine with cuprous N‐acetylcysteine mercaptide.