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Tritium labelling of antidepressants with regard to their chemical structure
Author(s) -
Buchman Ouri,
Azran Jacques,
Shimoni Michael
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200713
Subject(s) - chemistry , labelling , tritium , tricyclic , antidepressant , tricyclic antidepressant , chemical structure , radiochemistry , pharmacology , organic chemistry , biochemistry , psychology , neuroscience , nuclear physics , physics , medicine , hippocampus
Different methods of tritium incorporation have been applied to 14 available tricyclic antidepressant drugs. The specific activities of the labelled compounds are compared. The results are discussed by comparison with hydrogendeuterium exchange and with regard to the chemical structure of these derivatives.