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Synthese DE LA pentamethylmelamine (tetraméthyle 14 C), un nouvel agent antitumoral
Author(s) -
Hoellinger H.,
Pichat L.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200612
Subject(s) - chemistry , dimethylamine , yield (engineering) , toluene , column chromatography , nuclear chemistry , medicinal chemistry , chromatography , organic chemistry , materials science , metallurgy
Abstract (tetramethyl‐ 14 C)Pentamethylmelamine 6 , a new antitumor agent, was prepared by a three‐step synthesis starting with ( 14 C)CH 3 I. Toluene‐p‐sulphonamide was condensed with ( 14 C)CH 3 I to give labelled NN‐dimethyltoluene‐p‐sulphonamide. 14 C‐labelled dimethylamine was released from the dimethylamide by the action of 48% HBr and NaOH, then reacted with 2,4‐dichloro‐6‐methylamino‐1,3,5‐triazine to afford 6 . After purification by silicagel column chromatography 6 was obtained in a 8.5% yield from ( 14 C)CH 3 I and a radiochemical purity of 99%, specific activity : 78.5 mCi/mmole.