Premium
Synthesis of 13 C and 14 C labeled pirmenol hydrochloride
Author(s) -
Hicks James L.,
Huang C. C.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200611
Subject(s) - chemistry , hydrochloride , yield (engineering) , medicinal chemistry , salt (chemistry) , free base , chloride , organic chemistry , materials science , metallurgy
Pirmenol hydrochloride ( cis ‐(±)‐α‐[3‐(2,6‐dimethyl‐1‐piperidinyl)‐propyl]‐α‐phenyl‐2‐pyridinemethanol monohydrochloride, CI‐845), a new anti‐arrhythmic drug, was labeled with 13 C and 14 C. Labeled benzoyl chloride reacted with 2‐trimethylsilylpyridine to yield 2‐benzoylpyridine. Treatment of the latter with cis ‐1‐(3‐chloropropyl)‐2,6‐dimethylpiperidine gave pirmenol free base, which was subsequently converted to the HCl salt.