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Synthèse DE LA colchicine (méthoxyle‐1 14 C)
Author(s) -
Pontikis R.,
Hoellinger H.,
Pichat L.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200413
Subject(s) - chemistry , colchicine , yield (engineering) , demethylation , column chromatography , specific activity , radiochemistry , chromatography , nuclear chemistry , stereochemistry , organic chemistry , biochemistry , enzyme , medicine , gene expression , materials science , dna methylation , metallurgy , gene
1‐demethylcolchicine obtained by selective demethylation of colchicine was condensed with ( 14 C) CH 3 I to gave (1‐methoxy 14 C) colchicine 4 . After two purifications by silicagel column chromatography 4 was obtained in a 40% yield from ( 14 C) CH 3 I and a radiochemical purity of 99% (specific activity : 57 mCi/mmole).