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Labeled aryl fluorides from the nucleophilic displacement of activated nitro groups by 18 F‐F −
Author(s) -
Attiná Marina,
Cacace Fulvio,
Wolf Alfred P.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200408
Subject(s) - chemistry , nucleophile , nitro , fluoride , fluorine , aryl , nucleophilic aromatic substitution , molecule , medicinal chemistry , ion , displacement (psychology) , nitro compound , nucleophilic substitution , organic chemistry , inorganic chemistry , catalysis , alkyl , psychology , psychotherapist
Nucleophilic displacement of activated nitro groups by 18 F‐fluoride ion is an efficient route to fluorine‐18 labeled aromatics, which can be obtained in the no‐carrier‐added state if required. The basic features of the fluorodenitration process are comparatively evaluated, and the influence of the experimental variables on its course are discussed. Examples concerning the preparation of typical 18 F‐labeled aromatic molecules are reported.