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The synthesis of tritium‐labeled misonidazole
Author(s) -
Born Jerry L.,
Smith Brian R.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200311
Subject(s) - chemistry , misonidazole , tritium , radiochemistry , recrystallization (geology) , nitro , high performance liquid chromatography , imidazole , chromatography , organic chemistry , biochemistry , in vitro , paleontology , physics , alkyl , nuclear physics , biology
The 3 synthesis of tritium‐labelled misonidazole via the NaB H 4 reduction of 1‐(3‐methoxy‐2‐oxopropyl)‐2‐nitro‐1H‐imidazole is described. Purification of labeled misonidazole was accomplished by recrystallization. The purity of the labeled compound was verified by HPLC.