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Synthesis of p 125 I ‐amphetamine
Author(s) -
Duterte D.,
Morier E.,
le PoncinLafitte M.,
Rapin J. R.,
Rips R.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200119
Subject(s) - chemistry , periodate , yield (engineering) , amphetamine , iodine , medicinal chemistry , nuclear chemistry , organic chemistry , radiochemistry , medicine , materials science , dopamine , metallurgy
p ‐iodo‐amphetamine was synthesized by the Sandmeyer reaction from iodine and p ‐NH 2 ‐amphetamine, in which the amino aliphatic group was protected by an easily hydrolysable group: t‐butyloxycarbonyl. Iodine was obtained by oxidation of Na 125 I with periodate in an acidic medium. The yield was 50% with a specific activity of 25 mCi/mmol.