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Synthesis of dideuteromethylene hydrocarbons by copper catalyzed reaction of grignard reagents
Author(s) -
Elliger Carl A.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200117
Subject(s) - chemistry , reagent , dilithium , catalysis , alkyl , pyridine , organic chemistry , grignard reagent , copper , ion , deprotonation
The dilithium tetrachlorocuprate catalyzed reaction of Grignard reagents with long chain alkyl p‐toluenesulfonates provides specifically labelled dideuteromethylene hydrocarbons. The tosylate esters are readily obtained by LiAID 4 treatment of fatty acid methyl esters followed by tosylation in pyridine.