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Preparation of radiolabeled pregnenolone analogs. 21‐Fluoro‐ pregnenolone‐21‐ 18 F, 21‐fluoropregnenolone‐3‐acetate‐21‐ 18 F, 21‐fluoropregnenolone‐7‐ 3 H, and 21‐fluoropregnenolone‐3‐acetate‐7‐ 3 H
Author(s) -
Eng Robert R.,
Spitznagle Larry A.,
Trager William F.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200109
Subject(s) - chemistry , pregnenolone , nucleophilic substitution , acetonitrile , fluoride , medicinal chemistry , nucleophile , organic chemistry , inorganic chemistry , steroid , catalysis , biochemistry , hormone
21‐Fluoropregnenolone‐3‐acetate‐21‐ 1 8 F ( 4b ) and 21‐fluoropregnenolone‐21‐ 1 8 F ( 8 ) were synthesized by nucleophilic substitution of the iodo group of the corresponding 21‐iodo analogs by F‐fluoride in an acetonitrile solution of 18‐Crown‐6. 21‐Fluoropregnenolone‐3‐acetate‐ 7‐ 3 H ( 10b ) and 21‐fluoropregnenolone‐7‐ 3 H ( 9b ) were synthesized by reacting 21‐ethoxalyl pregnenolone‐7‐ 3 H ( 6b ) with perchloryl fluoride.