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Synthesis of 14 C‐ and 3 H‐labelled β ‐casomorphin‐5
Author(s) -
Hartrodt B.,
Toth G.,
Neubert K.,
Sirokmán F.,
Baláspiri L.,
Schulz H.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200107
Subject(s) - chemistry , tyrosine , specific activity , tritium , stereochemistry , residue (chemistry) , biochemistry , enzyme , physics , nuclear physics
β‐casomorphin‐5, tyrosyl‐prolyl‐phenylalanyl‐prolyl‐glicine, labelled with 14 C and 3 H in the N‐terminal tyrosine residue, was synthesized by stepwise elongation, using [Dit] 1 ‐β‐casomorphin‐5 as precursor for catalytic tritiation. The specific radioactivities of the two peptides were 1.6 mCi/mmol [59.2 MBq/mmol] and 44.1 Ci/mmol [1.63 /Bq/mmol], respectively. Both were biologically fully active as compared with a synthetic reference material.