Premium
Synthetic heparinoids labelled with 125 I and 35 S
Author(s) -
Sederel L. C.,
Kolar Z.,
Van Der Does L.,
Bantjes A.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580191015
Subject(s) - polyelectrolyte , chemistry , heparinoid , trimethylamine , sulfur trioxide , carboxylate , polymer chemistry , inorganic chemistry , organic chemistry , heparin , polymer , sulfur dioxide , biochemistry
The labelling of a water‐soluble synthetic polyelectrolyte, having anticoagulant activity, has been studied. The polyelectrolyte is derived from cis‐1,4‐polyisoprene and contains N‐sulfate and carboxylate groups. [ 125 I]‐Iodination of the polyelectrolyte, using the Chloramine‐T method and an electrolytic method, resulted in a [ 125 I]‐labelled polyelectrolyte from which release of the label occurred. Resulfation of a partially desulfated polyelectrolyte with a [ 35 S]‐sulfur trioxide trimethylamine complex resulted in a [ 35 S]‐labelled polyelectrolyte which showed no release of the label.