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An investigation of the kinetics of formamidine sulfinic acid (FSA) degradation in the preparation of technetium‐99m radiopharmaceuticals
Author(s) -
Jette D. C.,
Scott J. R.,
Sitarz W.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580191012
Subject(s) - chemistry , urea , degradation (telecommunications) , kinetics , base (topology) , technetium 99m , bisulfite , reaction rate constant , technetium , nuclear chemistry , chemical kinetics , radiochemistry , inorganic chemistry , organic chemistry , biochemistry , scintigraphy , nuclear medicine , mathematics , telecommunications , mathematical analysis , physics , gene expression , quantum mechanics , computer science , dna methylation , gene , medicine
Technetium‐99m glucoheptonate complex was prepared using formamidine sulfinic acid (FSA) as a reducing agent. The fraction of technetium which was complexed to glucoheptonate remained at less than 20 percent for the first 10 minutes. After 20 minutes, the complexed fraction was greater than 95 percent and remained at this level after 24 hours. The lag phase was attributed to the kinetics of the base catalyzed degradation of FSA to urea and bisulfite. The overall rate of FSA degradation was determined and found to be dependent on the concentration of base and the initial concentration of FSA. The rate of production of one of the degradation products, urea, was also measured and found to be dependent on the concentration of base, but independent of the initial FSA concentration. A reaction scheme for the degradation of FSA was proposed and the reaction rate constants for the products of this reaction were determined.