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The transfer of radioactivity of HSA‐containing samples of 125 I insulin preparations during their storage
Author(s) -
Kopoldová J.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580191011
Subject(s) - chemistry , insulin , human serum albumin , human insulin , radiochemistry , albumin , chromatography , serum albumin , biochemistry , endocrinology , medicine
In 125 I insulin preparations, preserved in the form of lyophilized solutions with human serum albumin, the transfer of radioactivity from the insulin molecules to the higher molecular weight fractions was observed. After one month storage this transfer corresponded to 7 % of the total radioactivity and it increased proportionally to the length of the storage of iodinated preparations under simultaneous decrease of their biological activity. The results obtained with stored 125 I insulin preparations and these preparations irradiated with external gamma‐source were compared and discussed.