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Radiohalogenation of non activated aromatic compounds via aryltrimethylsilyl intermediates
Author(s) -
Wilbur D. S.,
Anderson K. W.,
Stone W. E.,
O'Brien H. A.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580191008
Subject(s) - chemistry , aromaticity , reaction conditions , combinatorial chemistry , organic chemistry , catalysis , molecule
The utility of aryltrimethylsilyl derivatives to regiospecifically introduce carrier and no‐carrier‐added quantities of radiobromine and radioiodine into certain aromatic rings has been demonstrated. Using trimethylsilyltoluenes as a model system for aromatic rings that are not highly activated, conditions for the rapid and efficient incorporation of radiobromine and radioiodine were found. Reaction conditions necessary for the radiobrominations were very mild; however, the slower radioiodinations required elevated temperatures or highly acidic conditions.